There's FA Cup action on the cards for two Australians this weekend as another prepares for a massive top-of-the-table encounter.
Multiple players are involved in matches with major title ramifications, while Mark Milligan has a new manager to impress in Scotland.
Read on to discover when and where your Caltex Socceroos are in action!
AUSSIES ABROAD: Mooy and Ryan miss out but Milligan tastes success
AUSSIES ABROAD: Missed opportunity for Luongo, Irvine in Championship
FA Cup on the agenda
Mat Ryan will be out to help Brighton and Hove Albion into the final eight of the FA Cup when they host Derby County at 11:30pm on Saturday night.
The Seagulls are aiming to bounce back from a 3-1 loss to Burnley last time out and will move within one round of the semi-finals if they beat Frank Lampard's men.
Massimo Luongo also has the chance to progress beyond the fifth round with his Queens Park Rangers side entertaining Watford at 6:45am on Saturday.
Aaron Mooy and Jackson Irvine are among the Aussies afforded time to rest up and recharge this weekend.
Meanwhile, in Scotland, Mark Milligan and Hibernian are targeting three points against visiting Hamilton in what will be new manager Paul Heckingbottom's maiden match at the helm.
The former Barnsley and Leeds United boss takes charge in the Scottish Premiership for the first time at 2:00am on Sunday.
Martin Boyle, Tom Rogic and Daniel Arzani are all still sidelined.
Vukovic in crunch clash
Flying at the top of the Belgian Pro League, KRC Genk could go 14 points clear with four matches to play in the regular season when they visit second-placed Club Brugge.
Danny Vukovic kept a clean sheet in a 2-0 victory over Standard Liege last weekend and will hope for another at 12:30am on Monday as his side aim to establish a strong buffer ahead of the championship play-off rounds.
Awer Mabil's Midtjylland are also well in the hunt for silverware; currently three points off Danish leaders FC Copenhagen, they will look to keep up the pressure by prevailing at home to Aalborg at 5:00am on Tuesday.
Mustafa Amini's mid-table AGF are away against SonderjyskE at 5:00am on Saturday.
In Germany, Mathew Leckie is hoping to recover from injury in time for Hertha Berlin's home meeting with Werder Bremen in the Bundesliga (4:30am Sunday), while Robbie Kruse and VfB Stuttgart travel to Ingolstadt in the division below (11:00pm Saturday).
Leckie's match will be screened on beIN Sports.
Alex Gersbach could make his third straight Eredivisie start in NAC Breda's clash with Ajax at Johann Cruyff Arena at 10:15pm on Sunday.
That comes after table-topping PSV's trip to Heerenveen (5:45am Saturday), where Trent Sainsbury and Aziz Behich will be vying for minutes.
And in Cyprus, the penultimate fixture of AEK Larnaca's regular season sees them and striker Apostolos Giannou head to table-toppers APOEL Nicosia (2:00am Sunday).
GIANNOU: Striker helps AEK Larnaca to victory
Closer to home
Milos Degenek's focus this weekend is on Al Hilal's quarter-final clash with Egyptian outfit Al Ittihad Alexandria in the Arab Club Championship, which takes place at 3:30am on Sunday.
That means the Saudi Pro League spotlight falls on Matthew Jurman, whose Al Ittihad side venture to Al Raed at 4:20am on Saturday.
In the Hyundai A-League, Jamie Maclaren is sure to be eyeing a second goal in as many matches for Melbourne City in their match against Newcastle Jets at McDonald Jones Stadium at 7:50pm tonight.
Josh Risdon remains sidelined by injury meaning he will play no part for Western Sydney Wanderers away to Adelaide United on Saturday, but Chris Ikonomidis should be involved as Perth Glory host Brisbane Roar at 10:00pm.
Rhyan Grant and Sydney FC conclude Round 19 at home to Central Coast Mariners at 5:00pm on Sunday.
All Hyundai A-League matches are broadcast in Australia LIVE on Fox Sports and Kayo Sports.
ON THE MOVE: Risdon commits to Hyundai A-League expansion club