Borussia Dortmund, Chelsea and Anderlecht are among the big name opponents that lay ahead of our overseas-based Caltex Socceroos this weekend.
Here's a look at what's in store for some of our national team stars and hopefuls.
RYAN'S CHELSEA CHALLENGE
Less than a month after Brighton and Hove Albion's 2-0 defeat at Stamford Bridge, Mat Ryan gets a chance for revenge on Chelsea as the Premier League champions visit the Amex Stadium on Saturday.
That loss sparked a four-match winless run for Brighton, who will hope for a result to help stay clear of the bottom three.
Aaron Mooy's Huddersfield Town are also attempting to avoid a relegation scrap and will look for their first victory in six when they visit struggling Stoke City.
PROMOTION PRESSURE IN THE CHAMPIONSHIP
It's a packed schedule for Aussies in the Championship on Saturday.
Ahead of their EFL Cup clash with Manchester City, Bailey Wright's Bristol City launch a massive week with a six-pointer away to fellow promotion-chasers Derby County.
Aston Villa are also well in the mix to go up and Mile Jedinak's men need to continue their fine league form at home to Barnsley.
Just as impressive has been Massimo Luongo's form this season, with the midfielder scoring his second of the campaign last time out. His Queens Park Rangers have the chance to make it three on the trot when Middlesbrough visit Loftus Road.
Jackson Irvine should also hold his place for Hull City's trip to out-of-sorts Sunderland, while Millwall and twice-capped James Meredith head to Leeds United.
MACLAREN TO DEBUT?
Elsewhere in the UK, Jamie Maclaren is in contention to make the first appearance of his loan spell at Hibernian in a Scottish Cup fourth-round derby against Edinburgh rivals Hearts early Monday morning (AEDT).
Tom Rogic, who scored a stoppage-time winner in last season's Cup final, is likely to miss Celtic's meeting with second-tier Brechin City.
ON THE CONTINENT
Another Aussie goalkeeper is set to face his competition's reigning champions as Danny Vukovic's KRC Genk host Anderlecht on Monday morning (AEDT).
Mat Leckie is in for a similarly tough test when Hertha Berlin - beaten on their return from the winter break by Vfb Stuttgart - welcome Bundesliga giants Borussia Dortmund.
And it doesn't get any easier for Aziz Behich's Bursaspor, who host Turkish Super Lig leaders Istanbul Basaksehir, while national team prospect Awer Mabil and Pacos de Ferreira head to fellow Premeira Liga battlers Desportivo Aves.
Meanwhile, in the Netherlands, Craig Goodwin and compatriot Ken Dougall will hope to help Sparta Rotterdam out of a tough run of form against Excelsior, while Mark Birighitti's NAC Breda take on PEC Zwolle.